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MK-6892

Cat. No. M13986

All AbMole products are for research use only, cannot be used for human consumption.

MK-6892 Structure
Size Price Availability Quantity
5mg USD 300 In stock
10mg USD 455 In stock
25mg USD 550 In stock
50mg USD 1050 In stock
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Quality Control & Documentation
Biological Activity

MK-6892 is a potent, selective, and full agonist for the high affinity nicotinic acid (NA) receptor GPR109A. Ki and GTPγS EC50 of MK-6892 on the Human GPR109A is 4 nM and 16 nM, respectively.

Chemical Information
Molecular Weight 386.4
CAS Number 917910-45-3
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hyeon Young Kim, et al. Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor

[2] Hong C Shen, et al. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate

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