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Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively. Grazoprevir hydrate inhibits SARS-CoV-2 3CLpro activity.
| Molecular Weight | 784.92 |
| Formula | C38H52N6O10S |
| CAS Number | 1350462-55-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 50 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Protease Inhibitors (HCV)
[2] No authors listed. Grazoprevir
[3] No authors listed. Aust Prescr. Elbasvir/grazoprevir
[4] Dennis J Cada, et al. Hosp Pharm. Elbasvir/Grazoprevir
[5] Gillian M Keating. Drugs. Elbasvir/Grazoprevir: First Global Approval
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