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MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 values of approximately 3 nM.
| Molecular Weight | 565.62 |
| CAS Number | 1039758-22-9 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Ji Zhang, et al. Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis
| Related Acetyl-CoA Carboxylase Products |
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| CP-640186
CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. |
| Olumacostat glasaretil
Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). |
| CP-640186 HCl
CP-640186 Hcl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431. |
| PF-05175157
PF-05175157 is a potent Acetyl-CoA carboxylase (ACC1) inhibitor with IC50s of 23.5±1.1 nM (rat) and 27.0±2.7 nM (human). |
| Firsocostat (ND-630)
ND-630 is an ACC inhibitor of human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively. |
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