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MK-0557 is a highly selective, orally administered neuropeptide NPY5R antagonist (Ki =1.6 nM). MK-0557 antagonizes the effects of the NPY5R-selective agonist on body-weight gain and hyperphagia in C57BL/6J mice and significantly suppresses the body-weight gain in diet-induced obese (DIO) mice.
| Molecular Weight | 406.41 |
| Formula | C22H18FN4O3 |
| CAS Number | 328232-95-7 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Neuropeptide Receptor Products |
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JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors. |
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| CYM 9484
CYM 9484 is a potent NPY Y 2 receptor antagonist. |
| L-152,804
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| NTNCB hydrochloride
NTNCB hydrochloride is a potent and selective non-peptidic NPY Y 5 antagonist. |
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