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MJC13

Cat. No. M8301

All AbMole products are for research use only, cannot be used for human consumption.

MJC13 Structure

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Biological Activity

MJC13 inhibits the positive regulation of androgen receptor (AR) signaling by the cochaperone protein FKBP52. The molecule inhibits hormone-induced dissociation of the FKBP52, nuclear translocation of AR and AR dependent gene expression. MJC13 inhibits proliferation of the androgen-dependent prostate cancer cell lines LNCaP and LAPC4.

Chemical Information
Molecular Weight 272.17
Formula C13H15Cl2NO
CAS Number 200709-97-3
Solubility (25°C) DMSO: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Keisuke Maeda, et al. FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells

[2] Ji Ho Suh, et al. Similarities and Distinctions in Actions of Surface-Directed and Classic Androgen Receptor Antagonists

[3] Cheryl Storer Samaniego, et al. The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling

[4] Su Liang, et al. Quantification of a New Anti-Cancer Molecule MJC13 Using a Rapid, Sensitive, and Reliable Liquid Chromatography-Tandem Mass Spectrometry Method

[5] Su Liang, et al. Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer

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Keywords: MJC13 supplier, inhibitors, activators

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