All AbMole products are for research use only, cannot be used for human consumption.
Mitoxantrone dihydrochloride is a potent type II DNA topoisomerase inhibitor. Mitoxantrone dihydrochloride disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells, by intercalation. Mitoxantrone dihydrochloride increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone dihydrochloride also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells.
| Molecular Weight | 517.4 |
| Formula | C22H28N4O6.2HCl |
| CAS Number | 70476-82-3 |
| Solubility (25°C) | DMSO 30 mg/mL Water 60 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
[1] Scott LJ, et al. CNS Drugs. Mitoxantrone: a review of its use in multiple sclerosis.
| Related Topoisomerase Products |
|---|
| Amonafide
Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer. |
| Idarubicin
Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. |
| Dexrazoxane hydrochloride
Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. |
| Irinotecan Hydrochloride Trihydrate
Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I. |
| Topotecan hydrochloride
Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
