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MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2. Like the related compound MitoTEMPO , MitoTEMPOL combines an antioxidant moiety (here, TEMPOL, also known as 4-hydroxy-TEMPO) with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. MitoTEMPOL has been used to elucidate the role of mitochondria-derived superoxide in mitochondrial, cellular, and whole animal signaling.
| Molecular Weight | 583.56 |
| Formula | C32H42BrNO2P |
| CAS Number | 1101113-39-6 |
| Solubility (25°C) | DMSO 10 mg/mL Water 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Jan Trnka, et al. Free Radic Res. Antioxidant properties of MitoTEMPOL and its hydroxylamine
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