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Mito-TEMPO (MT) is a mitochondrial-targeted superoxide dismutase mimetic that protects the early stages of acetaminophen (APAP) hepatotoxicity by inhibiting the formation of peroxynitrite. Mito-TEMPO treatment inhibits APAP-induced EXPRESSION OF RIP3 kinase.
Pesticide Biochemistry and Physiology. 2024 Apr 27.
In vitro and in silico analyses reveal the toxicity of metolachlor to grass carp hepatocytes and the antagonism of melatonin
Mito-TEMPO purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | HepG2 cells |
| Preparation method | HepG2 cells were seeded at a concentration of 1 × 10^4 cells/well in 96-well NCPs for 5 days. After spheroid formation, the cells were treated with 15 mM APAP, 15 mM APAP + 10 µM of Mito-T, and 15 mM of APAP + 100 µM of NAC, for 48 h at 37 °C in 5% CO2. |
| Concentrations | 10 µM |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6J Jcl mice |
| Formulation | Mito-T (2–20 mg/kg) was suspended in saline and injected intraperitoneally into mice at a dose of 0.5 mL per 50 g of mouse body weight. |
| Dosages | 2–20 mg/kg |
| Administration | i.p. |
| Molecular Weight | 510.03 |
| Formula | C29H35ClN2O2P |
| CAS Number | 1334850-99-5 |
| Solubility (25°C) | DMSO 100 mg/mL Water 50 mg/mL |
| Storage | -20°C, dry, sealed |
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Products are for research use only. Not for human use. We do not sell to patients.
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