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Mito-Lonidamine (Mito-LND) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS). Mito-Lonidamine inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species, and induces autophagic cell death in lung cancer cells.
Mito-LND (7.5 μmol/kg; oral gavage; 5 days per week; for 3 consecutive weeks) significantly decreased tumor progression in athymic nude mice (5 weeks) injected with H2030BrM3 cells.
| Molecular Weight | 801.62 |
| Formula | C43H45BrCl2N3OP |
| CAS Number | 2361564-49-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage | -20°C, dry, sealed |
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| FCCP
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| KL1333
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