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Miglinide calcium is thought to stimulate insulin secretion by closing atP-sensitive K+ K channels in pancreatic beta cells. Miglinide has strong oral hypoglycemic activity and is structurally different from sulfonylureas, although it stimulates calcium influx by binding to sulfonylureas receptors on pancreatic β cells and closing K+ATP channels.
| Molecular Weight | 668.88 |
| Formula | C38H48CaN2O6 |
| CAS Number | 145525-41-3 |
| Form | Solid |
| Solubility (25°C) | DMSO >10mg/ml |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Phillippe HM, et al. Expert Opin Pharmacother. Mitiglinide for type 2 diabetes treatment.
[3] [No authors listed]. Drugs R D. Mitiglinide: KAD 1229, S 21403.
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| Doxapram hydrochloride hydrate
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| Gliquidone
Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| Pinacidil monohydrate
Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels. |
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