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MIPS-21335 is a PI3KC2α inhibitor, with IC50 of 7 nM. MIPS-21335 also inhibits PI3KC2β, p110α, p110β and p110δ with IC50 values of 0.043, 0.140, 0.386, 0.742 μM, respectively. MIPS-21335 has antithrombotic effect.
ApoE-/- mice exhibited the anticipated prothrombotic effect of hypercholesterolemia, with a 1.5-fold increase in thrombus volume in blood from ApoE-/- vs wild-type mice. This prothrombotic phenotype in blood from hypercholesterolemic mice was significantly reduced with PI3KC2α deficiency. Acute pharmacologic inhibition of PI3KC2α with MIPS-21335 similarly reduced thrombosis in blood from ApoE-/- mice.
| Molecular Weight | 487.47 |
| Formula | C24H21N7O5 |
| CAS Number | 2569296-51-9 |
| Storage | 4°C, dry, sealed |
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