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(-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity.
| Molecular Weight | 246.3 |
| Formula | C15H18O3 |
| CAS Number | 158440-71-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage | Powder -20°C |
[1] Haoyang Jiang, et al. Clin Cancer Res. Morning for Irofulven, What Could be fiNER?
[5] Mark Baekelandt. Curr Opin Investig Drugs. Irofulven (MGI Pharma)
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Dacarbazine (DTIC-Dome; DTIC) is an alkylating agent that acts as a purine nucleotide precursor analog to inhibit purine nucleotide synthesis, thereby inhibiting DNA/RNA Synthesis, and can be used in studies related to melanoma and Hodgkin's lymphoma. |
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