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(-)-Indolactam V

Cat. No. M11271

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(-)-Indolactam V Structure
Synonym:

Indolactam V

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Quality Control & Documentation
Biological Activity

(-) -IndolacTAM V is an activator of PKC, and the Ki values of η -CrD2 (PKCγ -substituted peptide) and γ -CrD2 (PKCγ -substituted peptide) are 3.36 nM and 1.03 μM, respectively. The Kd values for C1A and C1B domains of PKC were 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), respectively. At 137 nM (β-C1B), 138 nM (γ-C1A) and 213 nM (γ-C1B), it has antitumor activity.

Chemical Information
Molecular Weight 301.38
Formula C17H23N3O2
CAS Number 90365-57-4
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jingjing Wei, et al. J Chem Inf Model. Mechanistic Insights into the P450 TleB-Catalyzed Unusual Intramolecular C-N Bond Formation Involved in the Biosynthesis of Indolactam V

[2] Jan Stein, et al. ChemMedChem. Synthetic Indolactam V Analogues as Inhibitors of PAR2-Induced Calcium Mobilization in Triple-Negative Breast Cancer Cells

[3] Noah F Fine Nathel, et al. Chem Sci. Total syntheses of indolactam alkaloids (-)-indolactam V, (-)-pendolmycin, (-)-lyngbyatoxin A, and (-)-teleocidin A-2

[4] Zhengren Xu, et al. Org Biomol Chem. Total synthesis of (-)-indolactam V

[5] Yu Nakagawa, et al. J Am Chem Soc. Indolactam-V is involved in the CH/pi interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand

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Keywords: (-)-Indolactam V, Indolactam V supplier, PKC, inhibitors, activators

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