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MI-4F

Cat. No. M8668

All AbMole products are for research use only, cannot be used for human consumption.

MI-4F Structure

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Quality Control & Documentation
Biological Activity

MI-4F is mesoionic compound that exhibits potent anticancer activity against multiple cancer cell lines and in vivo. MI-4F induces apoptosis in HepG2 cells. MI-4F appears to inhibit calcium efflux through inhibition formation of mitochondrial permeability transition pore (MPTP). MI-4F inhibits superoxide dismutase. MI-4F is not susceptible to MDR transporters P-glycoprotein, ABCG2 and MRP1. MI-4F also inhibits ABCG2-mediated efflux of mitoxantrone.

Chemical Information
Molecular Weight 409.91
Formula C22H17ClFN3S
CAS Number 346460-45-5
Solubility (25°C) DMSO: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Amanda do Rocio Andrade Pires, et al. Antioxidant effect of 1,3,4-thiadiazolium mesoionic derivatives on isolated mitochondria

[2] Gustavo Jabor Gozzi, et al. Selective Cytotoxicity of 1,3,4-Thiadiazolium Mesoionic Derivatives on Hepatocarcinoma Cells (HepG2)

[3] Amanda do Rocio Andrade Pires, et al. Interaction of 1,3,4-thiadiazolium mesoionic derivatives with mitochondrial membrane and scavenging activity: Involvement of their effects on mitochondrial energy-linked functions

[4] Amanda do Rocio Andrade Pires, et al. Comparative study of the effects of 1,3,4-thiadiazolium mesoionic derivatives on energy-linked functions of rat liver mitochondria

[5] Andrea Senff-Ribeiro, et al. Antimelanoma activity of 1,3,4-thiadiazolium mesoionics: a structure-activity relationship study

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Keywords: MI-4F supplier, inhibitors, activators

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