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MI-2-2 

Cat. No. M28489

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MI-2-2  Structure

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Quality Control & Documentation
Biological Activity

MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation.

Chemical Information
Molecular Weight 415.5
Formula C17H20F3N5S2
CAS Number 1454920-20-7
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage -20°C, protect from light, dry, sealed
References

[1] Ichiroh Kato, et al. Int J Oncol. Menin‑MLL inhibitors induce ferroptosis and enhance the anti‑proliferative activity of auranofin in several types of cancer cells

[2] Xiaofan Ding, et al. Gastroenterology. Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas

[3] Masoud Vedadi, et al. Protein Sci. Targeting human SET1/MLL family of proteins

[4] Jing Ren, et al. Bioorg Med Chem Lett. Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface

[5] Aibin Shi, et al. Blood. Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

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  Catalog
Abmole Inhibitor Catalog




Keywords: MI-2-2  supplier, Epigenetic Reader Domain, inhibitors, activators

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