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MI-1 is a Menin-MLL interaction inhibitor. The mixed lineage leukemia (MLL) gene encodes MLL, a histone methyltransferase important in regulating gene transcription. MLL rearrangements and formation of fusion oncoproteins can block hematopoietic differentiation and increase proliferation, resulting in acute leukemias. Menin, encoded by the MEN1 gene, is a tumor suppressor associated with multiple endocrine neoplasia type 1. It also acts as an oncogenic co-factor of MLL fusion proteins. MI-1 inhibits Menin-MLL interaction with an IC50 of 1.9 micromolar.
| Molecular Weight | 387.57 |
| Formula | C19H25N5S2 |
| CAS Number | 433311-07-0 |
| Solubility (25°C) | DMSO: 15 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Kishor K Bhattarai, et al. The MI-1-mediated pest resistance requires Hsp90 and Sgt1
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