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Resmetirom (MGL-3196) is a liver-targeted selective agonist for the thyroid hormone receptor-β (THR-β) designed to increase cholesterol uptake into the liver and increase its metabolism. Resmetirom (MGL-3196) was well-tolerated at all doses with no dose-related adverse events or liver enzyme, ECG or vital-sign changes. Resmetirom (MGL-3196) showed a beneficial effect on lipid parameters.
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Source | Atherosclerosis (2013). Figure 1. MGL-3196 |
| Method | i.v. | |
| Cell Lines | mice | |
| Concentrations | 0.25, 1, 2.5, 5, 10, 20, 50, 100 and 200 mg | |
| Incubation Time | 24-h | |
| Results | MGL-3196 appeared safe and was well-tolerated at all doses and no maximal tolerated dose was reached. Adverse events were mild, not dose-related or considered related to study drug. There were no effects on 24-h Holter heart rate, ECG intervals including QTcF (Fridericia’s correction), or blood pressure. |
| Molecular Weight | 435.22 |
| Formula | C17H12Cl2N6O4 |
| CAS Number | 920509-32-6 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Bo Shen, et al. Efficacy and safety of drugs for nonalcoholic steatohepatitis
[3] Suzanna L Attia, et al. Evolving Role for Pharmacotherapy in NAFLD/NASH
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