All AbMole products are for research use only, cannot be used for human consumption.
MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM). MG 149, at 200 μM, inhibites about 90% of Tip60 activity but has no inhibitory impact on p300 and PCAF. MG 149 is essentially competitive with Ac-CoA and noncompetitive with the histone substrate. MG149 inhibits acetyltransferase activity of nuclear extract from tissue samples from different brain regions in mice. MG149 inhibits the p53 and the NF-κB pathways.
RADIATION RESEARCH. 2022 Oct 21.
MG149 Inhibits MOF-Mediated p53 Acetylation to Attenuate X-Ray Radiation-Induced Apoptosis in H9c2 Cells
MG149 purchased from AbMole
| Molecular Weight | 340.46 |
| Formula | C22H28O3 |
| CAS Number | 1243583-85-8 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Histone Acetyltransferase Products |
|---|
| Curcumin
Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification. |
| C646
C646 is a selective inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. C646 preferentially selective for p300 versus other acetyltransferases. |
| Remodelin
Remodelin is a novel, potent Acetyl-transferase NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. |
| Histone Acetyltransferase Inhibitor II
Histone Acetyltransferase Inhibitor II, insulin producing cells capable of secreting blood glucose regulating hormones, specially insulin, in response to physiological signals, method of production of said cells and uses thereof. |
| Anacardic Acid
Anacardic Acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
