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MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis.
MG-115 (0.1-10 μM; 24 h) dose-dependently decreases the viability of HepG2 cells. MG-115 (0.1-10 μM; 24 h) amplifies the reporter gene expression mediated by CWK18 DNA condensates.
| Molecular Weight | 461.59 |
| Formula | C25H39N3O5 |
| CAS Number | 133407-86-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage | -20°C, sealed |
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