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MF-766

Cat. No. M10857

All AbMole products are for research use only, cannot be used for human consumption.

MF-766  Structure

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Quality Control & Documentation
Biological Activity

MF-766 is a highly effective, selective and orally active EP4 antagonist.Ki The value is 0.23 nM. MF-766 behaves as a complete antagonist with its IC in functional detection50 1.4 nM (becomes 1.8 nM when 10% HS is present). MF-766 can be used for cancer and inflammatory disease research.

Chemical Information
Molecular Weight 478.46
Formula C27H21F3N2O3
CAS Number 1050656-06-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yun Wang, et al. Oncoimmunology. Combination of EP 4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells

[2] John Colucci, et al. Bioorg Med Chem Lett. Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain

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