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Methyl hesperidin could quench the intrinsic fluorescence of BSA and the quenching mechanism should be a combined quenching process. Hesperidin, hesperidin methyl chalone and phellopterin reduce TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium. Methylhesperidin exerts no obvious toxic effects in mice of either sex when administered at a level as high as 5.0% in the diet. Methyl hesperidin lacked any carcinogenicity for B6C3F1 mice in the 96-wk feeding regimen used in a study.
| Molecular Weight | 624.59 |
| Formula | C29H36O15 |
| CAS Number | 11013-97-1 |
| Form | Solid |
| Solubility (25°C) | Water |
| Storage | 4°C, protect from light |
[2] Kawabe M, et al. Toxicol Lett. Subchronic toxicity study of methyl hesperidin in mice.
[3] Kurata Y, et al. Food Chem Toxicol. Carcinogenicity study of methyl hesperidin in B6C3F1 mice.
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