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Methyl gallate is a polyphenol commonly found in the plant kingdom and is also an inhibitor of NLRP3, inhibiting the activation of NLRP3 inflammatory vesicles. In vitro, Methyl gallate is also a potent, highly specific inhibitor of herpes simplex virus (HSV) and has the ability to inhibit Treg cell migration.
| Molecular Weight | 184.15 |
| Formula | C8H8O5 |
| CAS Number | 99-24-1 |
| Form | Solid |
| Solubility (25°C) | Ethanol 50 mg/mL |
| Storage | RT |
[5] Deborah Bebout, et al. Acta Crystallogr Sect E Struct Rep Online. Methyl gallate
| Related NLR Products |
|---|
| Nodinitib-1
Nodinitib-1 (ML130) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. |
| Ruscogenin
Ruscogenin is an important steroid saponin extracted from Ophiopogon japonicum. It alleviates blood-brain barrier dysfunction induced by cerebral ischemia by inhibiting TXNIP/NLRP3 inflammatory body activation and MAPK pathway, and has significant anti-inflammatory and antithrombotic activities. |
| Procyanidin-B2
Procyanidin B2 is a natural flavonoid with anti-tumor and anti-oxidation effects. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway. |
| Oridonin
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Oridonin (NSC-250682) also acts as an inhibitor of AKT, with IC50 values of 8.4 and 8.9 μM for AKT1 and AKT2, respectively. |
| Shionone
Shionone, isolated from Aster Tataricus, is a triterpenoid compound with antitussive and anti-inflammatory activities. Shionone has a unique six-membered four-ring framework and a 3-oxygen-4-monomethyl structure. |
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