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Methoxy-X04 is a fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar β-sheet deposits. Brain penetrant.
Sci Adv. 2025 Feb 07;11(6):eadq6038.
Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer’s disease mouse model
Methoxy-X04 purchased from AbMole
| Molecular Weight | 344.4 |
| Formula | C23H20O3 |
| CAS Number | 863918-78-9 |
| Solubility (25°C) | DMSO 34.44 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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