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Methoxsalen (Oxsoralen) a naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia, is a compound used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet an irradiation. After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
| Molecular Weight | 216.19 |
| Formula | C12H8O4 |
| CAS Number | 298-81-7 |
| Solubility (25°C) | DMSO 37 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] No authors listed. IARC Monogr Eval Carcinog Risk Chem Hum. Methoxsalen
[4] B Ljunggren, et al. Acute methoxsalen intoxication
[5] F A de Wolff, et al. Clinical pharmacokinetics of methoxsalen and other psoralens
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