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Metadoxine blocks adipocyte differentiation by blocking the protein kinase A-camp response prime-binding protein (PKA-CREb) pathway.
| Molecular Weight | 298.293 |
| Formula | C8H11NO3.C5H7NO3 |
| CAS Number | 74536-44-0 |
| Solubility (25°C) | Water 90 mg/mL DMSO ≥ 30 mg/mL |
| Storage | 4°C, dry, sealed |
[3] Luisa Vonghia, et al. Eur J Intern Med. Acute alcohol intoxication
| Related PKA Products |
|---|
| H-89 Dihydrochloride
H-89 dihydrochloride is a selective inhibitor of protein kinase A (PKA) with an IC50 value of 135 nM. |
| Bucladesine Sodium Salt
Bucladesine, a membrane permeable selective activator of PKA, has a critical role in up-regulation of ChAT and VAChT gene expression in PC12 cells by activation of extracellular signal regulated kinase (ERK) in Ca2+- and PKA-dependent manner. |
| H-89
H-89 is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. |
| 8-Bromo-cAMP sodium salt
8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator. |
| 5-Iodotubercidin
5-IOdotubercidin (NSC 113939), an ATP analogue, is a potent inhibitor of adenosine kinase with an IC50 value of 26 nM. 5-IOdotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by activating phosphorylase and glycogen synthase. 5-IOdotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC, and Haspin inhibitors. |
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