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Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC50 = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.
| Molecular Weight | 334.41 |
| Formula | C20H22N4O |
| CAS Number | 916923-10-9 |
| Solubility (25°C) | DMSO: ≥5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Feng Gao, et al. Current scenario of tetrazole hybrids for antibacterial activity
[2] Jingyu Zhang, et al. Tetrazole hybrids with potential anticancer activity
[3] Sheng-Qiang Wang, et al. Tetrazole hybrids and their antifungal activities
[5] Elena A Popova, et al. Tetrazole Derivatives as Promising Anticancer Agents
| Related Potassium Channel Products |
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| Doxapram hydrochloride hydrate
Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| Gliquidone
Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| Pinacidil monohydrate
Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels. |
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