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Mepazine is a potent and selective inhibitor of MALT1 protease, with IC50s of 0.83 and 0.42 μM for inhibition of full-length GSTMALT1 and GSTMALT1 325-760 segments, respectively, and also affects the viability of ABC-DLBCL cells by enhancing apoptosis. Mepazine also affects the viability of ABC-DLBCL cells by enhancing apoptosis.
| Molecular Weight | 310.46 |
| Formula | C19H22N2S |
| CAS Number | 60-89-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] H C DENBER. Am J Psychiatry. Ineffectiveness of mepazine (pacatal)
[5] N BRUCKMAN, et al. Am J Psychiatry. Mepazine (pacatal); further report
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| SGR-1505
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