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Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide precursor of Melphalan, is an alkylated agent. Melflufen hydrochloride has antitumor activity against multiple myeloma cells and inhibits angiogenesis. Melflufen hydrochloride has irreversible damage to myeloma cell DNA and cytotoxic effects.
| Molecular Weight | 534.88 |
| Formula | C24H31Cl3FN3O3 |
| CAS Number | 380449-54-7 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related DNA Alkylator/Crosslinker Products |
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Dacarbazine (DTIC-Dome; DTIC) is an alkylating agent that acts as a purine nucleotide precursor analog to inhibit purine nucleotide synthesis, thereby inhibiting DNA/RNA Synthesis, and can be used in studies related to melanoma and Hodgkin's lymphoma. |
| Altretamine
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| Carmustine
Carmustine is an alkylating antineoplastic agent for inhibiting the growth of U87MG glioblastoma cells with IC50 of 1.42 μM. |
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