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Meglutol is an antilipidemic agent that lowers cholesterol, triglycerides, serum beta-lipoproteins, and phospholipids, and inhibits the activity of the rate-limiting enzyme of cholesterol biosynthesis, HMG-CoA reductase.
| Molecular Weight | 162.14 |
| Formula | C6H10O5 |
| CAS Number | 503-49-1 |
| Form | Solid |
| Solubility (25°C) | DMSO > 250 mg/mL |
| Storage | -20°C |
[2] Dylan E Jones et al. Clin Chim Acta. 3-Methylglutaric acid in energy metabolism
[3] I Yoshida. Ryoikibetsu Shokogun Shirizu. [3-Hydroxy-3-methylglutaryl-CoA-lyase deficiency]
[4] T Lerman-Sagie. Pediatr Neurol. Behr syndrome
[5] C L Greene et al. J Neurogenet. 3-Hydroxy-3-methylglutaric aciduria
| Related HMG-CoA Reductase Products |
|---|
| Fluvastatin sodium
Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor with IC50 value between 40 and 100 nM at human liver microsomes. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. |
| Rosuvastatin calcium
Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions. |
| Mevastatin
Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. |
| Pravastatin sodium
Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. |
| Clinofibrate
Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood. |
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