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Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist. Target: Progesterone Receptor Medroxyprogesterone (MP), is a steroidal progestin drug which was never marketed for use in humans. An acylated derivative, medroxyprogesterone acetate (MPA), is clinically used as a pharmaceutical medicine. Compared to MPA, MP is over two orders of magnitude less potent as a progestogen. As such, MP itself is not used clinically, though it has seen limited use in veterinary medicine under the trade name Controlestril in France. In addition, it is an metabolite of MPA.
| Molecular Weight | 344.49 |
| CAS Number | 520-85-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Nancy H Busen. Bone mineral density in adolescent women using depot medroxyprogesterone acetate
| Related Progesterone Receptor Products |
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Dienogest is an orally-active semisynthetic, steroidal progestogen (or progestin). |
| Gestodene
Gestodene is a synthetic progestin used as a contraceptive. |
| Altrenogest
Altrenogest is a progestogen structurally related to veterinary steroid trenbolone. |
| Dydrogesterone
Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. |
| Ethynodiol diacetate
Ethynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills. |
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