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MDMX/MDM2-IN-2

Cat. No. M41349

All AbMole products are for research use only, cannot be used for human consumption.

MDMX/MDM2-IN-2 Structure

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Quality Control & Documentation
Biological Activity

MDMX/MDM2-IN-2 is a potent p53-MDM2/MDMX dual inhibitors with Kis of 0.23 μM and 2.45 μM for MDM2 and MDMX, respectively.

Chemical Information
Molecular Weight 576.87
Formula C28H25Cl3FN3O3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Alyssa M Klein et al. Genes Dev. The roles and regulation of MDM2 and MDMX: it is not just about p53

[2] Divya Venkatesh et al. Genes Dev. MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

[3] Christine M Eischen. J Mol Cell Biol. Role of Mdm2 and Mdmx in DNA repair

[4] Orit Karni-Schmidt et al. Annu Rev Pathol. The Roles of MDM2 and MDMX in Cancer

[5] Mark Wade et al. Nat Rev Cancer. MDM2, MDMX and p53 in oncogenesis and cancer therapy

Related Mdm2 Products
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NSC 66811

NSC 66811 is a potent MDM2 inhibitor with Ki value of 120 nM, which disrupts MDM2-p53 interaction and activates p53 function.

Nutlin-3a

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Nutlin-3b

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SL-01

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  Catalog
Abmole Inhibitor Catalog




Keywords: MDMX/MDM2-IN-2 supplier, Mdm2, inhibitors, activators

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