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MDL 72527 is an inhibitor of polyamine oxidase (spermine oxidase SMO). It blocks the production of H2O2 and increases the cells survival. Polyamine catabolism is one of the major causes of the ROS production of prostate cells in general and androgen-induced enhancement of ROS in androgen-dependent CaP cells in particular. Reports suggest that androgen stimulation of prostate cancer results in accumulation of ROS, which lead to progression of cancer, such progression is control by MDL 72527.
| Molecular Weight | 265.22 |
| Formula | C12H20N2.2HCl |
| CAS Number | 93565-01-6 |
| Solubility (25°C) | Water 60 mg/mL DMSO 7 mg/mL |
| Storage | 4°C, dry, sealed |
[4] Nikolaus Seiler, et al. The polyamine oxidase inactivator MDL 72527
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