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MANS peptide TFA is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis.
MANS peptide TFA (0-100 μM, 12-24 h) inhibits migration and invasion of lung cancer cells CL1-0/F3, CL1-5, PC9 and A549 without causing toxicity to normal cells. MANS peptide TFA (0-100 μM, 16 h) inihibits MARCKS phosphorylation and PI3K and AKT phosphorylation, leads to downstream changes in Slug and E-cadherin expression levels, prevents the loss of cell-cell adhesion, alters epithelial-mesenchymal transition (EMT) characteristics of cancer cells, and thus decreases tumor metastasis.
MANS peptide TFA (50 nmol/injection, ip, every 3 days for 6 injection) inhibits tumor metastasis, without affecting tumorigenesis in PC9 xenograft NOD/SCID mice model.
Sequence: {Myristic acid-Gly}-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Ala-Lys-Gly-Glu-Ala-Ala-Ala-Glu-Arg-Pro-Gly-Glu-Ala-Ala-Val-Ala
| Molecular Weight | 2612.84 |
| Formula | C111H184N30O35.C2HF3O2 |
| CAS Number | 479482-23-0 (free base) |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage | -20°C, dry, sealed |
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