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Malabaricone C

Cat. No. M18830

All AbMole products are for research use only, cannot be used for human consumption.

Malabaricone C Structure
Size Price Availability Quantity
1mg USD 70 In stock
5mg USD 180 In stock
10mg USD 300 In stock
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Biological Activity

Malabaricone C is an orally active and noncompetitive sphingomyelin synthase (SMS) inhibitor with IC50 values of 3 μM and 1.5 μM for SMS 1 and SMS 2, respectively. Malabaricone C has anti-inflammatory effects, which is found in the fruits of Myristica cinnamomea King. Malabaricone C reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver, showing significant prevention of high fat diet-induced fatty liver in mice.

Chemical Information
Molecular Weight 358.43
Formula C21H26O5
CAS Number 63335-25-1
Solubility (25°C) DMSO 80 mg/mL
Storage 4°C, sealed
References

[1] Mrityunjay Tyagi, et al. Free Radic Biol Med. Thiol antioxidants sensitize malabaricone C induced cancer cell death via reprogramming redox sensitive p53 and NF-κB proteins in vitro and in vivo

[2] Madhuri Basak, et al. Antioxid Redox Signal. Malabaricone C Attenuates Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Ulceration by Decreasing Oxidative/Nitrative Stress and Inflammation and Promoting Angiogenic Autohealing

[3] Muhamad Aqmal Othman, et al. ACS Med Chem Lett. Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice

[4] Jungwon Kang, et al. Int Immunopharmacol. Malabaricone C suppresses lipopolysaccharide-induced inflammatory responses via inhibiting ROS-mediated Akt/IKK/NF-κB signaling in murine macrophages

[5] Suhyun Lee, et al. J Cell Biochem. Malabaricone C inhibits PDGF-induced proliferation and migration of aortic smooth muscle cells through induction of heme oxygenase-1

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Keywords: Malabaricone C supplier, Others, inhibitors, activators

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