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Mabuterol

Cat. No. M40721

All AbMole products are for research use only, cannot be used for human consumption.

Mabuterol Structure

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Quality Control & Documentation
Biological Activity

Mabuterol is a selective, orally active beta-2 adrenergic receptor (β2-AR) agonist. Mabuterol inhibits PDGF-BB-induced cell proliferation, increased intracellular Ca2+, and Drp-1, cyclinD1, and PCNA protein expression, and enhances Mfn-2 expression. Can be used in studies of airway obstruction and chronic obstructive pulmonary disease (COPD).

Chemical Information
Molecular Weight 310.74
Formula C13H18ClF3N2O
CAS Number 56341-08-3
Form Solid
Solubility (25°C) DMF 30 mg/mL
DMSO 30 mg/mL
Ethanol 30 mg/mL
Storage -20°C
References

[1] Liuyang Wang et al. Int J Pharm. Development of mabuterol transdermal patch: Molecular mechanism study of ion-pair improving patch stability

[2] Yaru Gu et al. Chem Biol Interact. Inhibitory effect of mabuterol on proliferation of rat ASMCs induced by PDGF-BB via regulating [Ca2+]i and mitochondrial fission/fusion

[3] Xiumei Lu et al. Biomed Chromatogr. Enantioselective pharmacokinetics of mabuterol in rats studied using sequential achiral and chiral HPLC

[4] K Amemiya et al. Arzneimittelforschung. Toxicology of mabuterol

[5] I Yamamoto et al. J Immunoassay. Enzyme immunoassay for mabuterol, a selective beta 2-adrenergic stimulant in the trachea

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Keywords: Mabuterol supplier, Adrenergic Receptor, inhibitors, activators

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