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LY2881835 

Cat. No. M28122

All AbMole products are for research use only, cannot be used for human consumption.

LY2881835  Structure

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Quality Control & Documentation
Biological Activity

LY2881835 is a potent and selective agonist of G protein-coupled receptor 40 (GPR40). LY2881835 has efficacious and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion. LY2881835 has the potential for the research of type 2 diabetes mellitus.

Chemical Information
Molecular Weight 491.62
Formula C33H33NO3
CAS Number 1292290-38-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Tingting Chen, et al. Eur J Med Chem. Design, synthesis and structure-activity relationship studies of GPR40 agonists containing amide linker

[2] Yanyun Chen, et al. Pharmacol Res Perspect. A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes

[3] Mikhail Krasavin, et al. Eur J Med Chem. Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835

[4] Mikhail Krasavin, et al. Bioorg Med Chem. Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835

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  Catalog
Abmole Inhibitor Catalog




Keywords: LY2881835  supplier, GPR/FFAR, inhibitors, activators

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