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LY2608204 is a potent used to treat type 2 diabetes. In a clinical trial, a study was performed to evaluate the safety and tolerability of LY2608204 in patients with type 2 diabetes.
| Cell Experiment | |
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| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
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| Animal models | Male Wistar rats at a weight of 225-250 g |
| Formulation | LY2608204 is suspended in a 1:1 mixture of solutol/ethanol in a bath sonicator (10% of total volume). The obtained suspension is then diluted with 9 volumes of 10% aqueous solutol solution. |
| Dosages | 1, 3, 6, 10, 20 and 30 mg/kg |
| Administration | Orally, rats are given a 2 g/kg oral glucose bolus 2 hours after LY2608204 administration. |
| Molecular Weight | 559.81 |
| Formula | C28H37N3O3S3 |
| CAS Number | 1234703-40-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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|---|
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AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM. |
| Dorzagliatin
Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a glucokinase (GK) activator, which improves glycaemic control and pancreatic β-cell function for type 2 diabetes. |
| AZD1656
AZD1656 is a potent, selective and orally active glucokinase (GK) activator, with an EC50 of 60 nM. |
| Cadisegliatin (TTP-399)
Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes. |
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