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Rabusertib (LY2603618) is an effective and selective Chk1 inhibitor with an IC50 of 7 nM.
Invest New Drugs. 2025 Jan 27.
Synergistic antitumor effect of MK-1775 and CUDC-907 against prostate cancer
Rabusertib (LY2603618) purchased from AbMole
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Source | Oncotarget (2017). Figure 2. LY2603618 |
| Method | Clonogenic survival | |
| Cell Lines | U2OS cells | |
| Concentrations | 0, 25, 50 or 100 nM | |
| Incubation Time | 24 hours | |
| Results | An exposure time of 24 hours to the inhibitors was chosen for the clonogenic survival assays to resemble a transient delivery of such inhibitors upon in vivo single injections. |
| Molecular Weight | 436.3 |
| Formula | C18H22BrN5O3 |
| CAS Number | 911222-45-2 |
| Solubility (25°C) | DMSO 12 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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