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LY2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation of the S6 subunit of ribosomes, thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation.LY2584702 exhibited anti-tumour activity in preclinical analysis.
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Source | PLoS One (2017). Figure 1. LY2584702 |
| Method | Isolation of human neutrophils and cell stimulations | |
| Cell Lines | human neutrophils cell | |
| Concentrations | 10 μM | |
| Incubation Time | 5 minutes | |
| Results | This led to a decrease in 20-OH- and 20-COOH-LTB4 levels, and an increase in LTB4 levels. In contrast, LY2584702 did not prevent the metabolism of LTB4 into 20-OH- and 20-COOH-LTB4 in thapsigargin-stimulated neutrophils |
| Molecular Weight | 445.42 |
| Formula | C21H19F4N7 |
| CAS Number | 1082949-67-4 |
| Solubility (25°C) | DMSO > 4.5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related S6 Kinase Products |
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| BI-D1870
BI-D1870 is an ATP-competitive, cell permeable and brain penetrated inhibitor of the p90 RSK (ribosomal S6 kinase) with IC50 values of 31 nM, 24 nM, 18 nM, 15 nM for RSK1, RSK2, RSK3, RSK4, respectively. |
| PF-4708671
PF-4708671 is a novel cell-permeable inhibitor of S6K1 with Ki/IC50 value of 20 nM/160 nM. PF4708671 inhibits MSK1 (IC50 of 0.95 μM) 4-fold more weakly than S6K1. |
| FMK
FMK is a potent and selective inhibitor of p90 ribosomal protein S6 kinaseRSK2 (wt) with IC50 of 15 nM, >600- and 200-fold selectivity for RSK2 than the C436V and T493M mutants. |
| SL 0101-1
SL-0101-1 is a selective p90 RSK inhibitor for RSK2 with IC50 of 89 nM. |
| Quercitrin
Quercitrin (Quercitrin) is a natural compound in bitter buckwheat, which has anti-inflammatory effects and has the potential to be used in cardiovascular disease research. |
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