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LY2444296

Cat. No. M28209

All AbMole products are for research use only, cannot be used for human consumption.

LY2444296 Structure
Synonym:

FP3FBZ

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Quality Control & Documentation
Biological Activity

LY2444296 is an orally bioavailable, high-affinity and selective short-acting kappa opioid receptor (KOPR) antagonist, with a Ki value of ∼1 nM. LY2444296 exhibits anti-anxiety like effects.

Chemical Information
Molecular Weight 408.44
Formula C24H22F2N2O2
CAS Number 1346133-11-6
Form Solid
Solubility (25°C) Ethanol 27.5 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hildegard A Wulf, et al. Psychopharmacology (Berl). Mediation of the behavioral effects of ketamine and (2R,6R)-hydroxynorketamine in mice by kappa opioid receptors

[2] Marta Valenza, et al. Psychopharmacology (Berl). Effects of Kappa opioid receptor blockade by LY2444296 HCl, a selective short-acting antagonist, during chronic extended access cocaine self-administration and re-exposure in rat

[3] Marta Valenza, et al. Psychopharmacology (Berl). "Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats"

[4] Peng Huang, et al. Eur J Pharmacol. Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test

[5] Peng Huang, et al. Neurosci Lett. Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests

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Keywords: LY2444296, FP3FBZ supplier, Opioid Receptor, inhibitors, activators

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