All AbMole products are for research use only, cannot be used for human consumption.
LY2409881 trihydrochloride is a potent and selective IKK2 inhibitor with IC50 of 30 nM. LY2409881 trihydrochloride inhibits constitutively activated NF-ƘB, and causes concentration- and time-dependent growth inhibition and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity. LY2409881 trihydrochloride is synergistic with doxorubicin and cyclophosphamide in SUDHL2 cell in inhibiting the cell growth, but not in LY1 cell.
In vivo, LY2409881 (50, 100, and 200 mg/kg, i.p.) significantly inhibits the tumor growth in SCID-beige xenograft mouse model.
| Cell Experiment | |
|---|---|
| Cell lines | OCI-LY10 cells |
| Preparation method | Cytotoxicity is evaluated using the CellTiter-Glo Reagent according to the manufacturer's manual. Experiments are carried out in 96-well plates, with each treatment in triplicate. Samples are taken at typically 24, 48, and 72 hours after treatment. Cytotoxicity is expressed by the decreasing percentage of live cells in each treatment relative to the untreated control from the same experiment. IC50 for each cell line is calculated using the CalcuSyn Version 2.0 software. |
| Concentrations | 25 μM |
| Incubation time | ~72 h |
| Animal Experiment | |
|---|---|
| Animal models | Five- to 7-week-old SCID beige mice |
| Formulation | 5% dextrose in water |
| Dosages | 50, 100, 200 mg/kg on day 1 and 4 of every week for 4 weeks |
| Administration | administered intraperitoneally |
| Molecular Weight | 594.43 |
| Formula | C24H32Cl4N6OS |
| CAS Number | 946518-60-1 |
| Solubility (25°C) | DMSO: ≥ 16 mg/mL warmed |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related IκB/IKK Products |
|---|
| BAY 11-7082
BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). |
| SC-514
SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) with IC50 of 3-12 μM. |
| TPCA-1
TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM. |
| BMS-345541 hydrochloride
BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IC50 values of 0.3 μM and 4 μM for IKK-2 and IKK-1 respectively). BMS-345541 binds at an allosteric site of IKK. |
| Bardoxolone Methyl
Bardoxolone Methyl is an IKK inhibitor with potent pro-apoptotic and anti-inflammatory activities, as well as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
