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LY-411575 is a selective, cell permeable gamma-secretase inhibitor with IC50 of 0.082 nM for cell-based γ-secretase. LY-411575 decreased overall thymic cellularity and impaired intrathymic differentiation at the CD4(-)CD8(-)CD44(+)CD25(+) precursor stage. LY-411575 reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Treatment with LY-411575 (LSN-411575) arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.
| Molecular Weight | 479.48 |
| Formula | C26H23F2N3O4 |
| CAS Number | 209984-57-6 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Gamma-secretase/Beta-secretase Products |
|---|
| DAPT
DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. DAPT inhibits the activation of Notch 1 signaling. |
| BMS-708163
BMS-708163 (Avagacestat) is a selective γ-secretase inhibitor (IC50 = 0.3 nM). |
| RO4929097
RO4929097 is a potent and selective inhibitor of γ-secretase and as a result is able to inhibit Notch pathway signaling. |
| MK-0752
MK-0752 is a potent, oral inhibitor of γ-secretase with IC50 of 5 nM in human SH-SY5Y cells. |
| LY2811376
LY2811376 is an orally available, non-peptidic β-secretase inhibitor with IC50 of 239 nM-249 nM. |
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