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LY 320135

Cat. No. M6932

All AbMole products are for research use only, cannot be used for human consumption.

LY 320135 Structure

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Quality Control & Documentation
Biological Activity

LY 320135 is a potent CB1 receptor antagonist/inverse agonist (Ki = 141 nM) with greater than 70-fold selectivity over CB2 receptors (Ki > 10 μM). Structurally dissimilar from SR 141716A and AM 251. Shows weak binding to both 5-HT2 (Ki = 6.4 μM) and muscarinic receptors (Ki = 2.1 μM).

Chemical Information
Molecular Weight 383.4
Formula C24H17NO4
CAS Number 176977-56-3
Solubility (25°C) DMSO 11.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Maruoka, et al. J Med Chem. Pyrimidine ribonucleotides with enhanced selectivity as P2Y6 receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate γ-ester modifications.

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