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LX7101

Cat. No. M13729

All AbMole products are for research use only, cannot be used for human consumption.

LX7101 Structure

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Quality Control & Documentation
Biological Activity

LX7101 is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively; also inhibits PKA with an IC50 less than 1 nM.

Chemical Information
Molecular Weight 451.52
CAS Number 1192189-69-7
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Graziella Ribeiro de Sousa, et al. Pharmacol Res. Should we keep rocking? Portraits from targeting Rho kinases in cancer

[2] Naohiro Sunamura, et al. Sci Rep. Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells

[3] Sandro Boland, et al. Bioorg Med Chem Lett. Design, synthesis and biological characterization of selective LIMK inhibitors

[4] Bryce A Harrison, et al. ACS Med Chem Lett. Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma

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  Catalog
Abmole Inhibitor Catalog




Keywords: LX7101 supplier, ROCK, inhibitors, activators

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