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Lupenone plays a role through the PI3K/Akt/mTOR and NF-κB signaling pathways. Lupenone has anti-inflammatory, antiviral, antidiabetic and anticancer activities. Lupenone is an orally active lupine-type triterpenoid isolated from Musa basjoo.
Spontaneous type 2 diabetic nephropathy db/db mouse models were given three levels of lupenone (24 or 12 or 6 mg/kg/d) via intragastric administration for six weeks, Lupenone protected type 2 diabetic nephropathy kidneys by regulating the NF-κB-mediated inflammatory response and TGF-β1/Smad/CTGF pathway-associated fibrosis.
| Molecular Weight | 424.70 |
| Formula | C30H48O |
| CAS Number | 1617-70-5 |
| Solubility (25°C) | Ethanol 9 mg/mL |
| Storage | 4°C, protect from light |
[4] Feng Xu, et al. Biomed Pharmacother. Beneficial health effects of lupenone triterpene: A review
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