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Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia.
| Molecular Weight | 565.7 |
| Formula | C31H36FN3O4S |
| CAS Number | 1187020-80-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage | 4°C, dry, sealed |
[3] Amber Edinoff, et al. Psychopharmacol Bull. Lumateperone for the Treatment of Schizophrenia
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