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Lubiprostone (Amitiza) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation. It is a bicyclic fatty acid (more precisely, prostaglandin E1) derivative that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM).
Another CAS# 333963-40-9
| Molecular Weight | 390.46 |
| Formula | C20H32F2O5 |
| CAS Number | 136790-76-6 |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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