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In vitro: LTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC50s are 5.8 and 8.5 μM for PI3K β and δ, respectively. LTURM34 shows potent and broad ranging antiproliferative activity. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line.
| Molecular Weight | 414.48 |
| Formula | C24H18N2O3S |
| CAS Number | 1879887-96-3 |
| Solubility (25°C) | 82 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related DNA-PK Products |
|---|
| NU7026
NU7026 is a DNA-PK inhibitor with IC50 of 0.23 μM. |
| KU-0060648
KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM. |
| CC-115
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). CC-115 inhibits PC-3 cells proliferation with an IC50 of 138 nM. CC-115 blocks both mTORC1 and mTORC2 signaling. |
| YU238259
YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays. |
| Compound 401
Compound 401 is a synthetic inhibitor of DNA-PK (IC50 = 0.28 μM) that also targets mTOR but not PI3K in vitro. |
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