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LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats.
| Molecular Weight | 300.78 |
| Formula | C11H9ClN2O2S2 |
| CAS Number | 1365060-22-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 125 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Yuguang Zhao, et al. Future Med Chem. Small-molecule inhibitors of carboxylesterase Notum
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