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LP 12 hydrochloride is a 5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.22, 7.3, 52.7 and 326 nM respectively). Induces relaxation of substance P-induced contractions in guinea pig ileum (EC50 = 1.77 μM).
| Molecular Weight | 518.13 |
| Formula | C32H39N3O.HCl |
| CAS Number | 1185136-22-4 |
| Solubility (25°C) | DMSO 38.86 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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